By airplane, in three steps:

1) Catania-Fontanarossa Airport.
2) Bus “INTERBUS” from Catania Airport to Ragusa-Centro Coach Station, Piazza Zama (1 hour 50 min). Check www.interbus.it for schedule and fare rates
3) Taxi from Piazza Zama to the hotel.
 
N.B. It is also possible to share, at a reduced price for Aisna guests,  an NCC limo service from Catania airport straight to the hotel. Ditta F. La Cognata, lcfrancesco88@gmail.com.
 
- Car rental at Catania Airport:
Best deals at: http://www.aeroporto.catania.it/aeroporto/dopo-l-atterraggio/autonoleggio/ , or:  https://www.autoeurope.it .
 
Or:
 
1) Comiso-Pio La Torre Airport. (highly recommended -- Ryanair flights, www.ryanair.prenota-voli.com, are extremely  cheap, less than 10 euros one way if bought in advance);
2) Bus “TUMINO” from the airport to Ragusa Ibla (40 min drive). Check http://www.tuminobus.it/lines/2  for schedule and fare rates
3) Taxi to the hotel
 
N.B. It is also possible to share, at a reduced price for Aisna guests,  an NCC limo service from Comiso airport straight to the hotel. Ditta F. La Cognata, lcfrancesco88@gmail.com.
 
- Car rental at Comiso-Pio La Torre Airport:
Best deals at: www.sicilybycar.it  or:  https://www.autoeurope.it .
 

By car, from north (Messina):

- Highway E45 from Messina to Rosolini, then SS115, through Ispica and Modica, to Ragusa (about  2 ½ hour).
 

By car, from the west coast (Palermo):

- Highway A19 from Palermo to Catania; then E45 from Catania to Rosolini, then SS115, through Ispica and Modica, to Ragusa (about 3 ½  hour).